| 2025-03-20 14:00:0020 marzo, 2025 | Medmaster Valle  | 4 - 3 |  Médicos Nariño Senior | 14:00:002:00 pm | S Grupo A, Senior | 2025 | | Fecha 1 |
| 2025-03-20 14:00:0020 marzo, 2025 | Multiregiones Senior  | 2 - 0 |  Medicauca Senior | 14:00:002:00 pm | S Grupo A, Senior | 2025 | | Fecha 1 |
| 2025-03-20 15:15:0020 marzo, 2025 | Selbogmed Senior  | 2 - 1 |  Selmed Magdalena Senior | 15:15:003:15 pm | S Grupo B, Senior | 2025 | | Fecha 1 |
| 2025-03-20 15:15:0020 marzo, 2025 | Bolívar Senior  | 1 - 2 |  Club Deportivo Médicos Tolima Sénior FC | 15:15:003:15 pm | S Grupo B, Senior | 2025 | | Fecha 1 |
| 2025-03-20 16:30:0020 marzo, 2025 | Médicos Antioquia Senior  | 7 - 2 | Equipo Invitado | 16:30:004:30 pm | S Grupo C, Senior | 2025 | | Fecha 1 |
| 2025-03-20 16:30:0020 marzo, 2025 | Cafeteros Medquindío Senior  | 3 - 1 |  Club Deportivo Selmed FC Atlántico | 16:30:004:30 pm | S Grupo C, Senior | 2025 | | Fecha 1 |
| 2025-03-21 09:15:0021 marzo, 2025 | Medmaster Valle | 1 - 1 | Medicauca Senior | 09:15:009:15 am | S Grupo A, Senior | 2025 | | Fecha 2 |
| 2025-03-21 09:15:0021 marzo, 2025 | Multiregiones Senior | 2 - 1 | Médicos Nariño Senior | 09:15:009:15 am | S Grupo A, Senior | 2025 | | Fecha 2 |
| 2025-03-21 10:30:0021 marzo, 2025 | Selbogmed Senior | 3 - 1 | Club Deportivo Médicos Tolima Sénior FC | 10:30:0010:30 am | S Grupo B, Senior | 2025 | | Fecha 2 |
| 2025-03-21 10:30:0021 marzo, 2025 | Bolívar Senior | 4 - 0 | Selmed Magdalena Senior | 10:30:0010:30 am | S Grupo B, Senior | 2025 | | Fecha 2 |
| 2025-03-21 11:45:0021 marzo, 2025 | Médicos Antioquia Senior | 4 - 0 | Club Deportivo Selmed FC Atlántico | 11:45:0011:45 am | S Grupo C, Senior | 2025 | | Fecha 2 |
| 2025-03-21 11:45:0021 marzo, 2025 | Cafeteros Medquindío Senior | 3 - 1 | Equipo Invitado | 11:45:0011:45 am | S Grupo C, Senior | 2025 | | Fecha 2 |
| 2025-03-22 09:15:0022 marzo, 2025 | Medmaster Valle | 2 - 1 | Multiregiones Senior | 09:15:009:15 am | S Grupo A, Senior | 2025 | | Fecha 3 |
| 2025-03-22 09:15:0022 marzo, 2025 | Medicauca Senior | 1 - 0 | Médicos Nariño Senior | 09:15:009:15 am | S Grupo A, Senior | 2025 | | Fecha 3 |
| 2025-03-22 10:30:0022 marzo, 2025 | Selbogmed Senior | 0 - 2 | Bolívar Senior | 10:30:0010:30 am | S Grupo B, Senior | 2025 | | Fecha 3 |
| 2025-03-22 10:30:0022 marzo, 2025 | Club Deportivo Médicos Tolima Sénior FC | 4 - 0 | Selmed Magdalena Senior | 10:30:0010:30 am | S Grupo B, Senior | 2025 | | Fecha 3 |
| 2025-03-22 11:45:0022 marzo, 2025 | Médicos Antioquia Senior | 0 - 0 | Cafeteros Medquindío Senior | 11:45:0011:45 am | S Grupo C, Senior | 2025 | | Fecha 3 |
| 2025-03-22 11:45:0022 marzo, 2025 | Club Deportivo Selmed FC Atlántico | 0 - 1 | Equipo Invitado | 11:45:0011:45 am | S Grupo C, Senior | 2025 | | Fecha 3 |
| 2025-03-23 09:15:0023 marzo, 2025 | Médicos Antioquia Senior | 0(3) - 0(2) | Cafeteros Medquindío Senior | 09:15:009:15 am | Senior | 2025 | | - |
| 2025-03-23 09:15:0023 marzo, 2025 | Medmaster Valle | 0 - 1 | Bolívar Senior | 09:15:009:15 am | Senior | 2025 | | - |
| 2025-03-23 10:30:0023 marzo, 2025 | Club Deportivo Médicos Tolima Sénior FC | 1 - 2 | Medicauca Senior | 10:30:0010:30 am | Senior | 2025 | | - |
| 2025-03-23 10:30:0023 marzo, 2025 | Multiregiones Senior | 1 - 0 | Selbogmed Senior | 10:30:0010:30 am | Senior | 2025 | | - |
| 2025-03-23 11:45:0023 marzo, 2025 | Equipo Invitado | 3 - 0 | Selmed Magdalena Senior | 11:45:0011:45 am | Senior | 2025 | | - |
| 2025-03-23 11:45:0023 marzo, 2025 | Médicos Nariño Senior | 0 - 4 | Club Deportivo Selmed FC Atlántico | 11:45:0011:45 am | Senior | 2025 | | - |
| 2025-03-24 07:00:0024 marzo, 2025 | Equipo Invitado | 1 - 3 | Club Deportivo Selmed FC Atlántico | 07:00:007:00 am | Senior | 2025 | | - |
| 2025-03-24 08:30:0024 marzo, 2025 | Médicos Antioquia Senior | 2 - 0 | Bolívar Senior | 08:30:008:30 am | Senior | 2025 | | - |
| 2025-03-24 10:00:0024 marzo, 2025 | Medicauca Senior | 0 - 2 | Multiregiones Senior | 10:00:0010:00 am | Senior | 2025 | | - |
| 2025-03-24 10:00:0024 marzo, 2025 | Club Deportivo Médicos Tolima Sénior FC | 1 - 3 | Selbogmed Senior | 10:00:0010:00 am | Senior | 2025 | | - |
| 2025-03-24 11:30:0024 marzo, 2025 | Cafeteros Medquindío Senior | 0(5) - 0(4) | Medmaster Valle | 11:30:0011:30 am | Senior | 2025 | | - |
