| 2025-03-20 14:00:0020 marzo, 2025 | Medmaster Valle – Senior  | 4 - 3 |  Médicos Nariño – Senior | 14:00:002:00 pm | S Grupo A, Senior | 2025 | | Fecha 1 |
| 2025-03-20 14:00:0020 marzo, 2025 | Multiregiones – Senior  | 2 - 0 |  Medicauca – Senior | 14:00:002:00 pm | S Grupo A, Senior | 2025 | | Fecha 1 |
| 2025-03-20 15:15:0020 marzo, 2025 | Selbogmed – Senior  | 2 - 1 |  Selmed Magdalena – Senior | 15:15:003:15 pm | S Grupo B, Senior | 2025 | | Fecha 1 |
| 2025-03-20 15:15:0020 marzo, 2025 | Bolívar – Senior  | 1 - 2 |  Club Deportivo Médicos Tolima Sénior FC | 15:15:003:15 pm | S Grupo B, Senior | 2025 | | Fecha 1 |
| 2025-03-20 16:30:0020 marzo, 2025 | Médicos Antioquia – Senior  | 7 - 2 | Equipo Invitado | 16:30:004:30 pm | S Grupo C, Senior | 2025 | | Fecha 1 |
| 2025-03-20 16:30:0020 marzo, 2025 | Cafeteros Medquindío – Senior  | 3 - 1 |  Club Deportivo Selmed FC Atlántico – Senior | 16:30:004:30 pm | S Grupo C, Senior | 2025 | | Fecha 1 |
| 2025-03-21 09:15:0021 marzo, 2025 | Medmaster Valle – Senior | 1 - 1 | Medicauca – Senior | 09:15:009:15 am | S Grupo A, Senior | 2025 | | Fecha 2 |
| 2025-03-21 09:15:0021 marzo, 2025 | Multiregiones – Senior | 2 - 1 | Médicos Nariño – Senior | 09:15:009:15 am | S Grupo A, Senior | 2025 | | Fecha 2 |
| 2025-03-21 10:30:0021 marzo, 2025 | Selbogmed – Senior | 3 - 1 | Club Deportivo Médicos Tolima Sénior FC | 10:30:0010:30 am | S Grupo B, Senior | 2025 | | Fecha 2 |
| 2025-03-21 10:30:0021 marzo, 2025 | Bolívar – Senior | 4 - 0 | Selmed Magdalena – Senior | 10:30:0010:30 am | S Grupo B, Senior | 2025 | | Fecha 2 |
| 2025-03-21 11:45:0021 marzo, 2025 | Médicos Antioquia – Senior | 4 - 0 | Club Deportivo Selmed FC Atlántico – Senior | 11:45:0011:45 am | S Grupo C, Senior | 2025 | | Fecha 2 |
| 2025-03-21 11:45:0021 marzo, 2025 | Cafeteros Medquindío – Senior | 3 - 1 | Equipo Invitado | 11:45:0011:45 am | S Grupo C, Senior | 2025 | | Fecha 2 |
| 2025-03-22 09:15:0022 marzo, 2025 | Medmaster Valle – Senior | 2 - 1 | Multiregiones – Senior | 09:15:009:15 am | S Grupo A, Senior | 2025 | | Fecha 3 |
| 2025-03-22 09:15:0022 marzo, 2025 | Medicauca – Senior | 1 - 0 | Médicos Nariño – Senior | 09:15:009:15 am | S Grupo A, Senior | 2025 | | Fecha 3 |
| 2025-03-22 10:30:0022 marzo, 2025 | Selbogmed – Senior | 0 - 2 | Bolívar – Senior | 10:30:0010:30 am | S Grupo B, Senior | 2025 | | Fecha 3 |
| 2025-03-22 10:30:0022 marzo, 2025 | Club Deportivo Médicos Tolima Sénior FC | 4 - 0 | Selmed Magdalena – Senior | 10:30:0010:30 am | S Grupo B, Senior | 2025 | | Fecha 3 |
| 2025-03-22 11:45:0022 marzo, 2025 | Médicos Antioquia – Senior | 0 - 0 | Cafeteros Medquindío – Senior | 11:45:0011:45 am | S Grupo C, Senior | 2025 | | Fecha 3 |
| 2025-03-22 11:45:0022 marzo, 2025 | Club Deportivo Selmed FC Atlántico – Senior | 0 - 1 | Equipo Invitado | 11:45:0011:45 am | S Grupo C, Senior | 2025 | | Fecha 3 |
| 2025-03-23 09:15:0023 marzo, 2025 | Médicos Antioquia – Senior | 0(3) - 0(2) | Cafeteros Medquindío – Senior | 09:15:009:15 am | Senior | 2025 | | - |
| 2025-03-23 09:15:0023 marzo, 2025 | Medmaster Valle – Senior | 0 - 1 | Bolívar – Senior | 09:15:009:15 am | Senior | 2025 | | - |
| 2025-03-23 10:30:0023 marzo, 2025 | Club Deportivo Médicos Tolima Sénior FC | 1 - 2 | Medicauca – Senior | 10:30:0010:30 am | Senior | 2025 | | - |
| 2025-03-23 10:30:0023 marzo, 2025 | Multiregiones – Senior | 1 - 0 | Selbogmed – Senior | 10:30:0010:30 am | Senior | 2025 | | - |
| 2025-03-23 11:45:0023 marzo, 2025 | Equipo Invitado | 3 - 0 | Selmed Magdalena – Senior | 11:45:0011:45 am | Senior | 2025 | | - |
| 2025-03-23 11:45:0023 marzo, 2025 | Médicos Nariño – Senior | 0 - 4 | Club Deportivo Selmed FC Atlántico – Senior | 11:45:0011:45 am | Senior | 2025 | | - |
| 2025-03-24 07:00:0024 marzo, 2025 | Equipo Invitado | 1 - 3 | Club Deportivo Selmed FC Atlántico – Senior | 07:00:007:00 am | Senior | 2025 | | - |
| 2025-03-24 08:30:0024 marzo, 2025 | Médicos Antioquia – Senior | 2 - 0 | Bolívar – Senior | 08:30:008:30 am | Senior | 2025 | | - |
| 2025-03-24 10:00:0024 marzo, 2025 | Medicauca – Senior | 0 - 2 | Multiregiones – Senior | 10:00:0010:00 am | Senior | 2025 | | - |
| 2025-03-24 10:00:0024 marzo, 2025 | Club Deportivo Médicos Tolima Sénior FC | 1 - 3 | Selbogmed – Senior | 10:00:0010:00 am | Senior | 2025 | | - |
| 2025-03-24 11:30:0024 marzo, 2025 | Cafeteros Medquindío – Senior | 0(5) - 0(4) | Medmaster Valle – Senior | 11:30:0011:30 am | Senior | 2025 | | - |
